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Israel targeted Hamas military leader Mohammed Deif in a series of strikes in southern Gaza on Saturday, an operation that killed at least 90 people and injured 300 more, according to the Gaza Health Ministry.

“There is still no absolute certainty” that Deif was killed, Israeli Prime Minister Benjamin Netanyahu said at a news conference. “But one way or another, we will reach every senior member of Hamas.”

An Israeli military official, speaking on the background in line with protocol, said the Israel Defence Forces had “precise intelligence” that Deif, the head of the Izzedine al-Qassam Brigades, was in a “compound” in the Mawasi area west of Khan Younis.

Netanyahu said intelligence suggested “there were no signs” Israeli hostages were in the area of the strike, which aid agencies and Gaza’s civil defence force said took place within Israel’s designated “humanitarian zone” in Mawasi.

“If Hamas senior leaders think they’ll build a compound and hide in a compound in an area where we called for them [civilians] to move to, we will hunt them down,” the military official said in a briefing with reporters. The strike also targeted Rafa Salama, a Hamas commander in Khan Younis, the military said.

“Killing any Hamas commander brings us closer to achieving our objectives” in Gaza, including freeing the hostages and eliminating “any future threat”, Netanyahu said.

The Gaza Health Ministry said on Saturday that at least 90 people were killed and 300 injured in the bombardment, with hospitals, clinics and emergency personnel struggling to treat the wounded. Hundreds of thousands of displaced people are staying in Mawasi – many of them in tents – after Israel issued evacuation orders for parts of Rafah, Gaza’s southernmost city, in May, and told civilians to seek shelter there.

“Paramedics are still trying to rescue people from under the sand,” Raed al-Nems, a spokesman for the Palestine Red Crescent Society, said. The first of several reported strikes began around 10.30am local time, witnesses said.

Hatem al-Attar, 25, is a member of Gaza’s civil defence force. He said he was injured by shrapnel when a missile hit the area around 11am, as he worked with colleagues to try to evacuate people from the site of the initial strike.

“We saw people’s legs, hands and other body parts flying in the air because of the force of the explosion,” Attar said by phone, adding that the area where the strike landed was “a lively street with thousands of displaced people”.

Israeli officials, speaking on condition of anonymity because they were not authorised to discuss the strike, described Deif and Salama as “two of the masterminds” of the October 7 attack. They did not provide details on the roles the commanders played.

In May, the chief prosecutor of the International Criminal Court, Karim Khan, announced that he was applying for an arrest warrant for Deif, along with other Hamas leaders, for war crimes and crimes against humanity. Among the charges Khan is seeking are rape, extermination and taking hostages.

Khan also requested arrest warrants for Israeli Prime Minister Netanyahu and Defence Minister Yoav Gallant, alleging the two leaders have used starvation of civilians as a method of warfare and intentionally directed attacks against civilians in Gaza.

Netanyahu said when Israel’s security service proposed the plan, he wanted to know “the extent of the collateral damage” and “the type of munitions that would be used”. The Israeli military official who briefed reporters on Saturday declined to say what munitions were used in the attack.

Deif, who was designated as a terrorist by the State Department in 2015, has survived multiple assassination attempts, although some of his family members have been killed in the operations.

Israeli forces see the targeting of Hamas leaders as key to eliminating the group, even as experts warn that there’s no single figurehead whose death would serve as a knockout blow to the movement.

Israel has killed several high-ranking Hamas officials since in October. Earlier this year, an Israeli drone strike in Beirut killed Saleh Arouri, deputy Hamas leader and one of the founders of the armed wing, the Izzedine al-Qassam Brigades. In March, an Israeli strike in Gaza’s Nuseirat refugee camp killed deputy military commander Marwan Issa.

In a statement on Saturday, Hamas denied reports that Israel targeted its leadership, saying that “these false allegations are merely to cover up the scale of the horrific massacre” and describing the attack as “a dangerous escalation”.

The Qassam Brigades alluded to the strike on Deif in a statement on Telegram, but did not explicitly confirm the leader’s death.

“There is no voice louder than the voice of Deif... There is no weapon like Deif’s weapon,” the post said. “May God reward you for this entire nation... may God continue his shadow and the fear that he strikes.”

Here’s what else to know

• - The office of Israeli PM Netanyahu denied any plans to withdraw from a 13km corridor separating Gaza from Egypt. A message posted on social media Friday said that Netanyahu insists that Israel will remain in the Philadelphi Corridor, after the Reuters news agency reported that Israel was exploring the possibility of using an electronic surveillance system along the border between Gaza and Egypt that would allow its troops to withdraw.
• - Rescue teams in Gaza City recovered dozens of bodies after Israeli forces ended an offensive and withdrew from the Tel al-Hawa and al-Sina’a areas on Friday, the Palestinian defence force said. Israel launched an operation in the city earlier this week and dropped leaflets urging all civilians in the area to evacuate south.
• - The Israeli military said on Friday that a soldier was killed in the north of the country, where Israel and the Iranian-backed Lebanese militant group Hezbollah have exchanged cross-border fire for months. The military did not say how the 33-year-old was killed, but the Haaretz newspaper reported that the soldier died after being wounded in a drone attack on Thursday.
• - At least 38,443 people have been killed and 88,481 injured in Gaza since the war started, the Gaza Health Ministry said. It does not distinguish between civilians and combatants but says the majority of the dead are women and children. Israel estimates that about 1200 people were killed in Hamas’ October 7 attack, including more than 300 soldiers, and it says 326 soldiers have been killed since the start of its military operations in Gaza.